The chameleon genus Brookesia is made up of species which were divided into two lineages. One of the lineages is made up of miniaturized species. Evolution of miniaturized body results in consequences to the survival of Brookesia.

Brookesia nana is known from a single location. Much about this species remains unknown which makes it difficult to evaluate conservation status. This species is at higher risk due to low elevation and deforestation, slash-and-burn agriculture, and cattle. Madagascar officials have established a reserve in Sorata mountain, in Madagascar, to protect remaining forest habitats and B. nana.